{"id":15373,"date":"2026-09-03T17:57:53","date_gmt":"2026-09-03T17:57:53","guid":{"rendered":"https:\/\/medical-article.com\/?p=15373"},"modified":"2026-09-03T17:57:53","modified_gmt":"2026-09-03T17:57:53","slug":"ultragenyx-trial-failure-revives-debate-about-how-to-treat-a-rare-neuro-disorder","status":"publish","type":"post","link":"https:\/\/medical-article.com\/?p=15373","title":{"rendered":"Ultragenyx Trial Failure Revives Debate About How to Treat a Rare Neuro Disorder"},"content":{"rendered":"<p><a href=\"https:\/\/medcitynews.com\/2026\/09\/ultragenyx-angelman-syndrome-apazunersen-rare-disease-antisense-oligonucleotide-aso\/\"><\/a><\/p>\n<p>Ultragenyx Pharmaceuticals\u2019 apazunersen did not meet the goals of its Phase 3 test in Angelman syndrome, a rare genetic neurological disorder with no FDA-approved therapies. The disappointing result has some readthrough to Ionis Pharmaceuticals and Oak Hill Bio, each in clinical development with Angelman drugs designed to work in a similar way as Ultragenyx\u2019s failed molecule. <\/p>\n<p>The post <a href=\"https:\/\/medcitynews.com\/2026\/09\/ultragenyx-angelman-syndrome-apazunersen-rare-disease-antisense-oligonucleotide-aso\/\">Ultragenyx Trial Failure Revives Debate About How to Treat a Rare Neuro Disorder<\/a> appeared first on <a href=\"https:\/\/medcitynews.com\/\">MedCity News<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>Ultragenyx Pharmaceuticals\u2019 apazunersen did not meet the goals of its Phase 3 test in Angelman syndrome, a rare genetic neurological disorder with no FDA-approved therapies. The disappointing result has some readthrough to Ionis Pharmaceuticals and Oak Hill Bio, each in clinical development with Angelman drugs designed to work in a similar way as Ultragenyx\u2019s failed&#8230;<\/p>\n","protected":false},"author":0,"featured_media":15374,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-15373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicine"],"_links":{"self":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts\/15373"}],"collection":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=15373"}],"version-history":[{"count":0,"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts\/15373\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/media\/15374"}],"wp:attachment":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=15373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=15373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=15373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}