{"id":5886,"date":"2025-05-21T11:10:20","date_gmt":"2025-05-21T11:10:20","guid":{"rendered":"https:\/\/medical-article.com\/?p=5886"},"modified":"2025-05-21T11:10:20","modified_gmt":"2025-05-21T11:10:20","slug":"inequalities-in-car-t-cell-therapy-access-for-us-patients-with-relapsed-refractory-dlbcl","status":"publish","type":"post","link":"https:\/\/medical-article.com\/?p=5886","title":{"rendered":"Inequalities in CAR T-Cell Therapy Access for US Patients with Relapsed\/Refractory DLBCL"},"content":{"rendered":"<p>That is the title of my <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40378343\/\">recent publication<\/a> with co-authors Andrea Chung, Sachin Vadgama, Kristen Hurley, Miguel-Angel Perales, Leonard Clarkson Alsfeld, Sanjana Muthukrishnan and Anik R Patel, Gunjan L Shah, Richard T Maziarz.  The abstract is below. <\/p>\n<p> CAR T-cell therapy has shown curative potential for patients with diffuse large B-cell lymphoma (DLBCL) and other malignancies, but its accessibility among Medicare patients, particularly in disadvantaged populations, remains uncertain. This study aims to assess CAR T utilization in Medicare patients with DLBCL receiving third-line or later (3L+) treatment, focusing on access disparities and their impact on clinical outcomes. Using SEER-Medicare data from 2007-2020, multivariate logistic regression was employed to evaluate patient characteristics and the effects of distance to authorized treatment centers (ATCs) on CAR T access. Between 2017 and 2020, 2,241 patients were treated for 3L+ DLBCL in the SEER-Medicare data, of which 122 (5.4%) received CAR T. CAR T recipients were less likely to have multiple comorbidities (OR=0.904, p = 0.001), but more likely to live in higher income areas (OR=1.176, p = 0.004). If distance to the nearest ATC for \u2018poor access\u2019 states (average distance to ATC=104.4 miles) decreased to the average distance in \u2018better access\u2019 states (34.2 miles), there would be a 37.6% increase in number of patients receiving CAR T (6.6% to 9.1%, p&lt;0.001). These findings highlight substantial disparities in CAR T utilization, driven by geographic and socioeconomic factors. Addressing these barriers could significantly enhance equitable access to CAR T therapy and improve outcomes for underserved populations, emphasizing the need for targeted interventions to reduce geographic and systemic barriers to care. <\/p>\n<p>You can read the full article <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40378343\/\">here<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>That is the title of my recent publication with co-authors Andrea Chung, Sachin Vadgama, Kristen Hurley, Miguel-Angel Perales, Leonard Clarkson Alsfeld, Sanjana Muthukrishnan and Anik R Patel, Gunjan L Shah, Richard T Maziarz. The abstract is below. CAR T-cell therapy has shown curative potential for patients with diffuse large B-cell lymphoma (DLBCL) and other malignancies,&#8230;<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-5886","post","type-post","status-publish","format-standard","hentry","category-articles"],"_links":{"self":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts\/5886"}],"collection":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5886"}],"version-history":[{"count":0,"href":"https:\/\/medical-article.com\/index.php?rest_route=\/wp\/v2\/posts\/5886\/revisions"}],"wp:attachment":[{"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medical-article.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}