What is the PICOSI framework?

When conducting evidence synthesis, many individuals use the PICO framework. PICO stands for population; intervention; comparator(s); and outcome. This helps to describe the research question that the evidence synthesis aims to answer. However, recently Remiro‐Azócar (2024) proposed PICOSI framework. PICOSI stands for: PopulationInterventionComparator(s)OutcomesSummary effect measure; Intercurrent events In fact, Canada’s Drug Agency’s (CDA) recent draft…

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Listen: NPR and KFF Health News Explore How Racism and Violence Hurt Health

KFF Health News Midwest correspondent Cara Anthony and Emily Kwong, host of NPR’s podcast “Shortwave,” talk about Black families living in the aftermath of lynchings and police killings in their communities. Anthony shares her southeastern Missouri-based reporting from “Silence in Sikeston,” a documentary film, podcast, and print reporting project. She discusses the latest research on…

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Weekend Links

Emily Oster on the power of nuance in public health.When did sustained economic growth begin?NYT: Rethinking drinking?Lex Fridman interviews Javier Milei (en español).Dumbest state “law” of the month

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My Totally Wrong, Expert Predictions for Health Care 2025

By MICHAEL MILLENSON January In a blistering commentary, the American Medical Association’s flagship journal, JAMA, condemns the corrosive effect on patient care of the profit-seeking practices of health insurers. Separately, the organization announces that it’s selling the 13 journals in its JAMA Network to a private equity firm for $375 million “in order to enhance…

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My Publications in 2024

Here is the list of my papers that were published in 2024. Manuscripts were published in Value in Health, BMJ Open, Journal of Comparative Effectiveness Research, Forum for Health Economics and Policy, Annals of the American Thoracic Society and others. Links to all papers are below. Clayton D, Shafrin J, Yen GP, Geevarghese L, Shi…

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“Comparisons Are Toxic.” True or False?

by MIKE MAGEE THCB is back from its end of year break, but we are starting with a little catchup from December from Mike Magee. As my wife often reminds me, “Comparisons are toxic.” And, in general, I agree and try to respect this cardinal rule. But these are extraordinary times. So grant me this…

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